GMP级重组人MUC-1蛋白（冻干粉）

Recombinant Human MUC-1 Protein

作用机理：

Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-

bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that

play an essential role in forming protective mucous barriers on epithelial surfaces. These

proteins also play a role in intracellular signaling. This protein is expressed on the apical

surface of epithelial cells that line the mucosal surfaces of many different tissues

including lung, breast stomach and pancreas. MUC-1/CC1/CD227 Exclusively located in the

apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis,

internalized and recycled to the cell membrane. This protein is proteolytically cleaved into

alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit

functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling.

Overexpression, aberrant intracellular localization, and changes in glycosylation of this

protein have been associated with carcinomas. The alpha subunit has cell adhesive properties.

MUC-1/CC1/CD227 Can act both as an adhesion and an anti-adhesion protein. This protein May

provide a protective layer on epithelial cells against bacterial and enzyme attack.

规格参数：

货号：TL-689 规格：200ug

产品信息：

表达宿主：人 HEK293 细胞

同源名称：Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1/SEC,MUC-1/X,MUC1/ZD,PEM,PEMT,PUM,CA 15-

3,Episialin

蛋白序列：DNA 序列编码人 MUC-1（UniProtKB/Swiss-Prot: P15941）表达带有 Fc 标签在 C 末端

分 子 量：重组人 MUC-1 蛋白包含 366 个氨基酸，预测理论分子量为 38.4 kd

纯 度：≥95%采用 SDS-PAGE 凝胶和高效液相色谱分析

内 毒 素：＜0.1EU/ug

纯化方式：层析纯化

性 状：白色疏松体

保存温度：2-8℃

有 效 期：24 个月

生产厂家：同立海源生物

使用说明：

稳定性和储存：冻干的样本的可以在 4℃保存 24 个月，溶解后的液体可以于-20℃保存 6-12 个月，并且避

免反复冻融。

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