扶正疏肝方联合左旋甲状腺素对甲状腺结节的干预作用

杨小玲;谢军芳

【期刊名称】《国际中医中药杂志》

【年(卷),期】2016(038)009

【摘要】目的：观察扶正疏肝方干预甲状腺结节的临床效果。方法选择2014年1月－2015年12月渭南市第一医院甲状腺结节患者80例，按随机数字表法分为2组，每组40例。对照组口服左旋甲状腺素，观察组在对照组基础上加用自拟扶正疏肝方治疗。2组均治疗3个月。采用化学发光法检测血清促甲状腺激素水平；采用彩色多普勒血流显像检测甲状腺结节，评价临床效果。结果观察组总有效率(90.00%比27.50%)高于对照组(χ2＝32.237，P＝0.000)。治疗后，观察组呼吸不畅[(1.62±0.86)分比(4.35±1.13)分，t＝12.159]、咽喉异物感[(2.53±0.62)分比(4.36±0.71)分，t＝12.289]、烦躁易怒[(1.56±0.53)分比(3.52±1.25)分，t＝9.130]、失眠多汗[(1.85±0.62)分比(4.23±0.56)分，t＝18.017]、舌有瘀斑[(1.58±0.93)分比(3.71±1.25)分，t＝8.646]、颈部刺痛[(0.82±0.35)分比(3.92±0.65)分，t＝26.558]证候积分均低于对照组(P＜0.05)；观察组促甲状腺激素水平[(1.05±0.21)mIU/L 比(2.16±0.71)mIU/L，t＝9.482]、结节最大径[(8.52±4.72)mm 比(12.27±5.69)mm，t＝3.208]、结节体积[(0.26±0.71)cm3比(0.96±1.02)cm3，t＝3.562]、高危因素积分[(2.73±1.45)分比(4.05±1.36)分，t＝4.199]均低于对照组(P＜0.01)。结论扶正疏肝方可扶正疏肝、消肿散结，联合口服左旋甲状腺素对甲状腺结节有效。%Objective To investigate the clinical effect ofFuzheng-Shugan decoction on the treatment of patients with the treatment nodule.Methods A total of 80 patients with thyroid nodule from Jan.2014 to Dec.2015, divided into two groups. The efficacy, thyroid stimulating hormone, high risk factors, the maximum diameter and volume of thyroid nodules were observed.Results The effective rate of observation group was significantly higher than of the control group (90.00%vs.27.50%,χ2=32.237,P=0.000). The shortness of breath (1.62 ± 0.86vs. 4.35 ± 1.13,t=12.159), foreign body sensation (2.53 ± 0.62vs. 4.23 ± 0.56,t=12.289), irritability (1.56 ± 0.53vs. 3.52 ± 1.25,t=9.130), sweating (1.85 ± 0.62vs.4.23 ± 0.56,t=18.017), tongue (1.58 ± 0.93vs. 3.71 ± 1.25,t=8.646) and neck pain (0.82 ± 0.35vs. 3.92 ± 0.65,t=26.558) in the obversation group were significantly lower than those in the control group (P<0.05). The thyroid stimulating hormone levels in the observation group (1.05 ± 0.21 mIU/Lvs. 2.16 ± 0.71 mIU/L,t=9.482), were significantly lower (P<0.05). The maximum diameter (8.52 ± 4.72 mmvs. 12.27 ± 5.69 mm,t=3.208) nodule volume (0.26 ± 0.71 cm3vs. 0.96 ± 1.02 cm3,t=3.562) and high risk factors (2.73 ± 1.45vs. 4.05 ± 1.36,t=4.199) in the observation group were significantly lower than those in the control group (P<0.05).Conclusion TheFuzheng-Shugan decoction can improve TCM syndrome, reduce the risk factors, and effectively reduce the nodule maximum diameter and volume.